Appetite W/ Iron

Multivitamins, iron, buclizine HCl, lysine HCl.

Capsule: Each capsule contains: Retinol (Vitamin A) 3,000 IU, Cholecalciferol (Vitamin D₃) 300 IU, Thiamine mononitrate (Vitamin B₁) 15 mg, Riboflavin as sodium phosphate (Vitamin B₂) 1 mg, Nicotinamide 20 mg, Pyridoxine HCl (Vitamin B₆) 5 mg, Cyanocobalamin (Vitamin B₁₂) 5 mcg, Iron (equivalent to 186 mg Ferrous sulfate monohydrate) 60 mg, Buclizine HCl 25 mg, Lysine HCl 25 mg.
APPETITE WITH IRON is a pale cream powder contained in black/scarlet capsule that contains Vitamin A, D, Buclizine HCl, Lysine HCl and Iron. It also includes B-complex Vitamins B₁, B₂, B₆, B₁₂, Nicotinamide at safe levels.
Syrup: Each 5 mL (1 teaspoonful) contains: Thiamine hydrochloride (Vitamin B₁) 15 mg, Riboflavin sodium phosphate (Vitamin B₂) 1 mg, Nicotinamide (Vitamin B₃) 20 mg, Pyridoxine HCl (Vitamin B₆) 5 mg, Cyanocobalamin (Vitamin B₁₂) 5 mcg, Iron (equivalent to 75 mg Ferrous Sulfate heptahydrate) 15 mg, Buclizine HCl 5 mg, Lysine HCl 100 mg.

Pharmacology: Pharmacodynamics: THIAMINE (Vitamin B₁): Thiamine also helps improve muscle tone of the stomach, intestines, heart and blood vessels. Thiamine is involved in releasing energy from the macronutrients which provide energy, especially from carbohydrates. Thiamine enhances production of energy from glucose and storage of energy as fat, making energy available to support normal cellular processes.
RIBOFLAVIN (Vitamin B₂): Riboflavin is involved in a wide array of essential biochemical oxidation-reduction reactions, especially those that yield energy. It is converted to two other coenzymes that are necessary for normal tissue respiration and energy production.
NICOTINAMIDE (Vitamin B₃): Nicotinamide performs all the essential biochemical functions of Niacin. It has a fundamental role as reduction/oxidation coenzymes essential for tissue respiration, lipid metabolism and glycogenolysis, involved in energy metabolism and detoxification reactions for drugs and other substances.
PYRIDOXINE (Vitamin B₆): Vitamin B₆ in blood and tissues occurs phosphorylated in three primary forms. These pyridoxines are pyridoxol (the alcohol), pyridoxal (the aldehyde) and pyridoxamine (the amine). The activated forms of pyridoxal and pyridoxamine are the active coenzyme forms, and the inter-conversion between them is involved in many of the biological functions of the vitamin. This vitamin is required for many enzymatic reactions and extensively involved in the metabolism of amino acids and other nitrogen-containing compounds, and also in the metabolism of lipids and the production and activities of certain hormones. These include transam-ions, deamination, decarboxylation, and sulfation. It plays a part in protein metabolism, the synthesis of fat from protein, haemopoiesis and nutrition of the skin.
CYANOCOBALAMIN (Vitamin B₁₂): Vitamin B₁₂ is a large complex compound consisting of porphyrin ring containing cobalt. Cyanocobalamin functions as an integral part of the cobarnide enzymes which are involved in nucleic acid synthesis, carbohydrate metabolism, lipid metabolism, and amino acid metabolism. Cyanocobalamin is a cofactor in two enzymes that are fundamental in facilitating growth essential for the function and maintenance of central nervous system. Severe deficiency in cases of pernicious anemia produces a neurological disease called posterolateral spinal cord degeneration. The immediate cause of pernicious anemia is Vitamin B₁₂ deficiency but the underlying defect is the absence of intrinsic factor produced by cells of the stomach needed for intestinal absorption of Vitamin B₁₂. Therefore, daily high oral intake can be sufficient to treat pernicious anemia.
IRON: Iron is used in the synthesis of hemoglobin, an essential component of myoglobin in muscle, cytochromes, and other enzymes (e.g. antioxidant enzyme catalase).
BUCLIZINE HCl: Buclizine HCl is mainly used for anti-emetic action and as an appetite stimulant that increase both appetite and absorption of food in the body. It does not affect the growth hormone levels and it can maintain weight gain even after discontinuation of treatment.
LYSINE HCl: Lysine as an essential amino acid is a necessary building block for all protein in the body. It plays a major role in calcium absorption, building muscle protein; recovering from surgery or sports-related injuries and is utilized in the production of antibodies, hormones and enzymes which aid in digestion. Also, it can act as an appetite enhancer and is needed for proper growth and bone development in children. It aids in the improvement of calcium absorption and lessens loss of calcium in the urine.
Capsule: RETINOL ACETATE (Vitamin A): Vitamin A has essential actions in vision, cellular differentiation, and organ development during embryonic and fetal growth, membrane structure and function, including growth, reproduction, and immune system functions.
Vitamin A is fat-soluble and readily accumulates in the liver and structurally related to and possess the biological activity of the parent substance of the group called all-trans retinol or retinal.
CHOLECALCIFEROL (Vitamin D₃): Vitamin D is fundamentally involved in the formation of bone, and regulation of intestinal absorption and plasma concentration of calcium.
Vitamin D metabolites (The first hydroxylation of vitamin D₃ cholecalciferol (or D₂) occurs in the liver to yield 25-hydroxyvitamin D while the second hydroxylation happens in the kidneys to give 1, 25-dihydroxyvitamin D) subsequently facilitate the active absorption of calcium and phosphorus in the small intestine, serving to increase serum calcium and phosphate levels sufficiently to allow bone mineralization.
Pharmacokinetics: Thiamine is absorbed from the GI tract and is widely distributed to most body tissues. It is not stored to any appreciable extent in the body and amounts in excess of requirements are excreted in the urine as unchanged thiamine or metabolites.
Riboflavin is absorbed from the GI tract and in the circulation is bound to plasma proteins. Although widely distributed, little is stored in the body, and amounts in excess of requirements are excreted in the urine.
Nicotinamide is readily absorbed from the GI tract following oral administration and is widely distributed in the body tissues. Small amounts of nicotinamide are excreted unchanged in urine following therapeutic doses, however, the amount excreted unchanged is increased with larger doses.
Pyridoxine is absorbed from the GI tract and is converted to the active form pyridoxal phosphate. It is stored mainly in liver with lesser amounts in muscle and brain. It also crosses the placenta and is distributed into milk. It is excreted in the urine as 4-pyridoxic acid.
Cyanocobalamin is irregularly absorbed from the distal small intestine following oral administration. It requires gastric intrinsic factor for active absorption from the GI tract. It is distributed into liver, bone marrow, and other tissues. It also crosses the placenta and is distributed into milk. More than 50-98% may be excreted in urine.
Ferrous sulfate (Iron) is absorbed greatly in duodenum and proximal jejunum. Only 10% of iron is absorbed in the GI tract. Iron is excreted at least 1mg/day in nails, hair, feces and urine.
Buclizine is readily absorbed in the GI tract. Its onset of action is after one hour and the duration of the drug ranges from 4-6hrs.
Lysine upon ingestion is absorbed from the lumen of the small intestine into the enterocytes via active transport and moves from the gut to the liver via the portal circulation. Once in the liver, lysine joins other amino acids to facilitate protein synthesis. Lysine is rapidly transported into muscle tissue, within 5-7 hours after ingestion, and is more concentrated in the intracellular space of muscle tissue compared to other essential amino acids.
Capsule: Retinol acetate is readily absorbed from the normal gastrointestinal tract. Plasma concentrations reach a peak level within 3-5 hrs.
Cholecalciferol is well absorbed in the GI tract. Presence of bile is essential for adequate intestinal absorption. Hence absorption may be decreased in patients with decreased fat absorption. Excreted mainly in the bile and feces with only small amounts appearing in urine.

Capsule: Stimulates appetite and enhances weight gain with supplementary essential vitamins, iron deficiency anemia, anorexia nervosa and malnutrition. Used for convalescence and recovery in post-op conditions and body weakness due to illness.
Syrup: Improves appetite, enhances height, increase and promote weight gain. Nutritional supplement for vitamin deficiencies, during increased physical and mental activities, stress, fatigue, general body weakness and unbalanced diet.
Prevention and treatment of iron deficiency anemia, anemia during growth, prolonged illnesses and convalescence.

Capsule: 1 capsule twice a day, dosage may be increased depending on the patient's need or as prescribed by the physician.
Syrup: 2-6 yrs. old: 5 mL (1 teaspoonful).
7-14 yrs. old: 10 mL (2 teaspoonfuls).
Above 14 yrs. old: 15 mL (1 tablespoonful).
To be taken daily or as prescribed by the physician. Iron is best absorbed on an empty stomach (1 hour or before 2 hours before meals). This medication may be taken with food if stomach upset occurs.

Capsule: Diarrhea, nausea, constipation, and abdominal discomfort. In case of accidental overdose, discontinue use and seek medical assistance immediately.

Contraindicated in patients with history of hypersensitivity to the components, in patients receiving blood transfusions, peptic ulceration, ulcerative colitis and regional enteritis. Use cautiously in long-term therapy.

Capsule: As with any medication, women who are pregnant or breastfeeding should seek the advice of a doctor before using this product. Do not exceed recommended daily dose.
Buclizine hydrochloride may cause drowsiness and patients taking the drug should be cautioned against engaging in activities requiring mental alertness like driving automobile. Also, it has central nervous system depressant effect and may potentiate other CNS depressant compounds.
Syrup: Buclizine may cause drowsiness and patients taking the drug should be cautioned against engaging in activities requiring mental alertness like driving automobile. It has central nervous system depressant effect and may potentiate other CNS depressant compounds. It may be distributed in milk and inhibit lactation.

Capsule: As with any medication, women who are pregnant or breastfeeding should seek the advice of a doctor before using this product. Do not exceed recommended daily dose.
Syrup: It may be distributed in milk and inhibit lactation.

GI tract: nausea, epigastric pain, vomiting, constipation, black stools, diarrhea, drowsiness and dulling of mental alertness, dry mouth, headache and tiredness.
Syrup: Buclizine may cause urinary retention, angle-closure glaucoma and decrease gastric motility.

Capsule: Vitamins: high dose of calcium and phosphorus containing compounds, drugs with same content to avoid overdose, antibiotics, isotretinoin, non-steroidal anti-inflammatory drugs, anticoagulants, insulin, HMG-CoA reductase inhibitors, milk and levodopa.
Vitamin D: antiepileptics, corticosteroids, rifampicin and isoniazid.
Buclizine: alcohol, antihistamines, and other CNS depressants.
Ferrous sulfate: antacids, chloramphenicol, levodopa, penicillamine, quinolones, and dairy products.
Syrup: Vitamins: High dose of calcium and phosphorus containing compounds, drugs with same content to avoid overdose, antibiotics, isotretinoin, non-steroidal anti- inflammatory drugs, anticoagulants, insulin, HMG-CoA reductase inhibitors, milk and levodopa.
Ferrous sulfate: Antacids, chloramphenicol, levodopa, penicillamine, quinolones, and dairy products.
Buclizine: CNS depressants, alcohol, antihistamines, anticholinergics and apomorphine.

Store at temperatures not exceeding 30°C.
Syrup: Protect from light.
Shelf-Life: Capsule: 24 months.
Syrup: 36 months.

Appetite Enhancers

R06AE51 - buclizine, combinations ; Belongs to the class of piperazine derivatives used as systemic antihistamines.

Cap: Rx; Syr: Non-Rx